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講準字178號:蟲媒病毒生命周期的故事:從宿主到蚊子的捕獲機理

發布時間:2019-06-15|瀏覽次數:

講座報告主題:蟲媒病毒生命周期的故事:從宿主到蚊子的捕獲機理
專家姓名:程功
日期:2019-06-21 時間:08:40
地點:會議中心第一報告廳
主辦單位:生命科學研究院  

主講簡介:清華大學醫學院基礎醫學系研究員、博導,曾榮獲國家杰出青年科學基金、藥明康德生命化學研究獎、談家楨生命科學創新獎、中源協和生命醫學創新突破獎、樹蘭醫學青年獎、Grand Challenge青年科學家、牛頓高級學者。研究專長:研究方向為蟲媒病毒性傳染病的致病機理及疫苗研發,研究主要涉及登革熱病毒、乙型炎病毒、基孔肯亞熱等蚊媒病毒在哺乳動物宿主及節肢動物媒介中的感染機制。

主講內容:Arboviruses naturally circulate between vertebrate hosts and an arthropod vectors. Viral acquisition from an infected mammalian host by a vector is one of essential steps in their lifecycles. However, little information is available regarding the molecular mechanisms underlying the viral acquisition by arthropod vectors. Here, we will introduce multiple mechanisms in mosquito-borne viral acquisition, including: 1) A gut commensal bacteria promote mosquito susceptibility to arboviruses by blood meal; 2) Nonstructural protein-1 (NS1), which is abundantly secreted into the serum of an infected host, is a key factor for flavivirus acquisition from infected hosts to fed mosquitoes; 3) the hematophagous nature of mosquitoes contributes to arboviral acquisition after a blood meal, via suppressing antiviral innate immunity by activating the GABAergic pathway. Altogether, our studies demonstrate that arboviruses smartly utilize multiple materials, either produced in their vertebrate phases or existing in vectors, to enhance their acquisition by vectors, therefore facilitating arbovirus survival in nature.


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